Confident Phosphorylation Site Localization Using the Mascot Delta Score
نویسندگان
چکیده
منابع مشابه
Phosphorylation site localization in peptides by MALDI MS/MS and the Mascot Delta Score.
Owing to its broad biological significance, the large-scale analysis of protein phosphorylation is more and more getting into the focus of proteomic research. Thousands of phosphopeptides can nowadays be identified using state-of-the-art tandem mass spectrometers in conjunction with sequence database searching, but localizing the phosphate group to a particular amino acid in the peptide sequenc...
متن کاملThe formalisation of software development using MASCOT
ed from. Constraint 4 ensures that, while transitions may become defined on amalgamated modes, the actions available at each step will be the same. This, coupled with constraint 2, which ensures that the initial modes of sts2 are suitably related by US to initial modes in stsl, means that sts2 IES derivations have the same observable behaviour as stsl IES derivations. (2) The second clause of S...
متن کاملThe MASCOT Magnetometer
The Mobile Asteroid Scout (MASCOT) is a small lander on board the Hayabusa2 mission of the Japan Aerospace Exploration Agency to the asteroid 162173 Ryugu. Among the instruments on MASCOT is a fluxgate magnetometer, the MASCOT Magnetometer (MasMag). The magnetometer is a lightweight (∼ 280 g) and low power (∼ 0.5 W) triaxial fluxgate magnetometer. Magnetic field measurements during the landing ...
متن کاملRobust prediction of the MASCOT score for an improved quality assessment in mass spectrometric proteomics.
Protein identification by tandem mass spectrometry is based on the reliable processing of the acquired data. Unfortunately, the generation of a large number of poor quality spectra is commonly observed in LC-MS/MS, and the processing of these mostly noninformative spectra with its associated costs should be avoided. We present a continuous quality score that can be computed very quickly and tha...
متن کاملLocalization of PKA phosphorylation site, Ser(2030), in the three-dimensional structure of cardiac ryanodine receptor.
PKA (protein kinase A)-dependent phosphorylation of the cardiac Ca2+-release channel/RyR2 (type 2 ryanodine receptor)is believed to directly dissociate FKBP12.6 (12.6 kDa FK506-binding protein) from the channel, causing abnormal channel activation and Ca2+ release. To gain insight into the structural basis of the regulation of RyR2 by PKA, we determined the three-dimensional location of the PKA...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular & Cellular Proteomics
سال: 2011
ISSN: 1535-9476
DOI: 10.1074/mcp.m110.003830